:root {
  font-family: 'Inter', 'Segoe UI', system-ui, -apple-system, BlinkMacSystemFont, 'Helvetica Neue', sans-serif;
  color: #0f172a;
  background-color: #0f172a;
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  background: #0f172a;
  min-height: 100vh;
}

body.modal-open {
  overflow: hidden;
}

.gpe-app {
  max-width: 1280px;
  margin: 0 auto;
  padding: 2rem clamp(1.5rem, 2vw, 3rem) 3rem;
}

.gpe-hero {
  background: linear-gradient(135deg, #111827, #1f2937);
  color: #f8fafc;
  padding: 2rem;
  border-radius: 1.5rem;
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 1rem;
  box-shadow: 0 15px 40px rgba(15, 23, 42, 0.4);
}

.gpe-kicker {
  text-transform: uppercase;
  letter-spacing: 0.2em;
  font-size: 0.7rem;
  color: #a5b4fc;
  margin: 0 0 0.5rem;
}

.gpe-hero h1 {
  margin: 0;
  font-size: clamp(2rem, 3vw, 2.75rem);
}

.gpe-subtitle {
  margin: 0.25rem 0 0;
  color: #cbd5f5;
}

.gpe-btn-primary,
.gpe-btn-secondary,
.gpe-btn-design {
  border: none;
  border-radius: 999px;
  cursor: pointer;
  font-weight: 600;
  transition: transform 0.15s ease, box-shadow 0.2s ease;
  text-align: center;
}

.gpe-btn-primary {
  background: #a855f7;
  color: #fff;
  padding: 0.85rem 1.5rem;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  text-align: center;
  gap: 0.5rem;
  box-shadow: 0 15px 30px rgba(168, 85, 247, 0.4);
}


.gpe-btn-icon {
  font-size: 1.25rem;
}

.gpe-btn-secondary {
  background: #0f172a;
  color: #fff;
  padding: 0.65rem 1.25rem;
  margin-top: 0.75rem;
  width: 100%;
}

.gpe-layout {
  margin-top: 2rem;
  display: grid;
  grid-template-columns: 260px 1fr 320px;
  gap: 1.5rem;
}

.gpe-card {
  background: #fff;
  border-radius: 1rem;
  box-shadow: 0 15px 35px rgba(15, 23, 42, 0.15);
  overflow: hidden;
}

.gpe-hidden-panel {
  display: none;
}

.gpe-card-header {
  padding: 1rem 1.5rem;
  font-weight: 600;
  border-bottom: 1px solid #e2e8f0;
}

.gpe-card-body {
  padding: 1.5rem;
  display: flex;
  flex-direction: column;
  gap: 1rem;
}

.gpe-card-copy {
  margin: 0;
  color: #6b7280;
  font-size: 0.85rem;
}

.gpe-card-note {
  font-size: 0.8rem;
  color: #4b5563;
}

.gpe-upload-actions {
  display: flex;
  gap: 0.75rem;
  flex-wrap: wrap;
  align-items: center;
}

.gpe-upload-actions input[type="text"] {
  flex: 1;
  min-width: 160px;
  border-radius: 0.75rem;
  border: 1px solid #e2e8f0;
  padding: 0.55rem 0.75rem;
  font-size: 0.85rem;
}

.gpe-upload-actions .gpe-btn-secondary {
  padding: 0.55rem 1rem;
  margin-top: 0;
  width: auto;
}

.gpe-panel-details {
  display: flex;
  flex-direction: column;
  gap: 0.4rem;
  margin-bottom: 0.75rem;
}

.gpe-panel-details input {
  width: 100%;
  border-radius: 0.75rem;
  border: 1px solid #e2e8f0;
  padding: 0.65rem 0.75rem;
  font-size: 0.9rem;
}

.gpe-radio-group {
  display: flex;
  gap: 0.75rem;
}

.gpe-radio {
  display: flex;
  align-items: center;
  gap: 0.35rem;
  font-size: 0.85rem;
  color: #0f172a;
}

.gpe-radio input[type="radio"] {
  accent-color: #a855f7;
}

.gpe-file-btn {
  border-radius: 999px;
  border: 1px dashed #a855f7;
  color: #a855f7;
  padding: 0.55rem 1.25rem;
  font-weight: 600;
  cursor: pointer;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  transition: background 0.15s ease, color 0.15s ease;
}

.gpe-file-btn:hover {
  background: #f3e8ff;
}

.gpe-file-btn input[type="file"] {
  display: none;
}

.gpe-modal {
  position: fixed;
  inset: 0;
  display: none;
  align-items: center;
  justify-content: center;
  z-index: 2000;
}

.gpe-modal.show {
  display: flex;
}

.gpe-modal-overlay {
  position: absolute;
  inset: 0;
  background: rgba(15, 23, 42, 0.65);
}

.gpe-modal-dialog {
  position: relative;
  background: #fff;
  border-radius: 1rem;
  padding: 1.5rem;
  max-width: 420px;
  width: calc(100% - 2rem);
  box-shadow: 0 25px 60px rgba(15, 23, 42, 0.35);
  z-index: 1;
}

.gpe-modal-close {
  position: absolute;
  top: 0.75rem;
  right: 0.75rem;
  border: none;
  background: transparent;
  font-size: 1.25rem;
  cursor: pointer;
  color: #475569;
}

.gpe-panel-list {
  display: flex;
  flex-direction: column;
  gap: 0.75rem;
}

.gpe-panel-item {
  width: 100%;
  border: 1px solid #e5e7eb;
  border-radius: 0.75rem;
  padding: 0.9rem 1rem;
  background: #fff;
  text-align: left;
  cursor: pointer;
  transition: border-color 0.2s ease, box-shadow 0.2s ease;
  display: grid;
  gap: 0.35rem;
}

.gpe-panel-item .name { font-weight: 600; }
.gpe-panel-item .desc { font-size: 0.8rem; color: #6b7280; }
.gpe-panel-item .count { font-size: 0.75rem; color: #475569; }
.gpe-panel-item .gpe-panel-includes { font-size: 0.7rem; color: #0f172a; }

.gpe-panel-item.active,
.gpe-panel-item:hover {
  border-color: #a855f7;
  box-shadow: 0 12px 25px rgba(79, 70, 229, 0.2);
}

.gpe-panel-view {
  background: #fff;
  border-radius: 1.5rem;
  padding: 1.5rem;
  box-shadow: 0 20px 40px rgba(15, 23, 42, 0.1);
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
}

.gpe-panel-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 1rem;
}

.gpe-label {
  text-transform: uppercase;
  letter-spacing: 0.2em;
  font-size: 0.65rem;
  color: #94a3b8;
  margin-bottom: 0.35rem;
}

.gpe-controls {
  display: flex;
  align-items: center;
  gap: 0.75rem;
}

.gpe-controls input {
  border-radius: 999px;
  border: 1px solid #e2e8f0;
  padding: 0.4rem 0.75rem;
  font-size: 0.85rem;
  background: #fff;
}

.gpe-view-toggle {
  background: #f1f5f9;
  padding: 0.25rem;
  border-radius: 999px;
}

.gpe-view-btn {
  border: none;
  background: transparent;
  border-radius: 999px;
  padding: 0.4rem 0.9rem;
  font-size: 0.75rem;
  cursor: pointer;
  transition: background 0.15s ease;
}

.gpe-view-btn.active {
  background: #fff;
  box-shadow: 0 4px 15px rgba(148, 163, 184, 0.5);
}

.gpe-composition {
  display: flex;
  height: 18px;
  border-radius: 999px;
  overflow: hidden;
  border: 1px solid #e2e8f0;
}

.gpe-composition-segment { cursor: pointer; }

.gpe-tooltip {
  position: fixed;
  padding: 0.35rem 0.6rem;
  background: #0f172a;
  color: #fff;
  border-radius: 6px;
  font-size: 0.7rem;
  opacity: 0;
  pointer-events: none;
  transition: opacity 0.15s ease;
  z-index: 1000;
}

.gpe-tooltip.show { opacity: 1; }

.gpe-filter-row {
  min-height: 32px;
}

.gpe-filter-row #filterContainer {
  display: flex;
  align-items: center;
  flex-wrap: wrap;
}

.gpe-filter-chip {
  background: #f8fafc;
  border: 1px solid #e2e8f0;
  border-radius: 999px;
  padding: 0.25rem 0.85rem;
  font-size: 0.72rem;
  margin: 0 0.35rem 0.35rem 0;
  cursor: pointer;
}

.gpe-filter-chip .count { color: #94a3b8; margin-left: 0.25rem; }

.gpe-filter-chip.active {
  background: #111827;
  color: #fff;
  border-color: #111827;
}

.gpe-panel-body {
  min-height: 280px;
}

.gpe-empty {
  border: 1px dashed #d1d5db;
  border-radius: 1rem;
  padding: 2rem;
  text-align: center;
  color: #6b7280;
  font-size: 0.95rem;
}

.gpe-empty-emoji { font-size: 2.75rem; margin-bottom: 0.5rem; }

.gpe-gene-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(95px, 1fr));
  gap: 0.5rem;
}

.gpe-gene {
  border: 1px solid #e2e8f0;
  border-radius: 0.75rem;
  padding: 0.75rem 0.5rem;
  text-align: center;
  font-weight: 600;
  font-size: 0.85rem;
  cursor: pointer;
  background: #fff;
  transition: border-color 0.15s ease, transform 0.1s ease;
}

.gpe-gene:hover { border-color: #a855f7; transform: translateY(-1px); }
.gpe-gene.matched { background: #ecfccb; border-color: #a3e635; }
.gpe-gene.selected { box-shadow: 0 0 0 2px #a855f7 inset; }

.gpe-gene-tags {
  display: flex;
  justify-content: center;
  flex-wrap: wrap;
  gap: 2px;
  margin-top: 0.4rem;
}

.gpe-tag-dot {
  width: 6px;
  height: 6px;
  border-radius: 50%;
  display: inline-flex;
}

.gpe-gene-details {
  border: 1px solid #e2e8f0;
  border-radius: 1rem;
  padding: 1rem;
  background: #f8fafc;
}

.gpe-gene-symbol {
  font-size: 1.5rem;
  font-weight: 700;
}

.gpe-gene-list {
  display: flex;
  flex-wrap: wrap;
  gap: 0.35rem;
  margin-top: 0.35rem;
}

.gpe-empty-note {
  font-size: 0.75rem;
  color: #6b7280;
}

.gpe-gene-chip {
  border: 1px solid #e5e7eb;
  padding: 0.15rem 0.6rem;
  border-radius: 999px;
  font-size: 0.72rem;
  background: #fff;
}

.gpe-gene-chip.found { background: #dcfce7; border-color: #16a34a; color: #166534; cursor: pointer; }
.gpe-gene-chip.not-found { background: #dbeafe; border-color: #3b82f6; color: #1d4ed8; }
.gpe-gene-chip.unknown { background: #fee2e2; border-color: #ef4444; color: #991b1b; }

.gpe-chip-editor {
  width: 80px;
  border-radius: 6px;
  border: 1px solid #c7d2fe;
  font-size: 0.75rem;
  padding: 0.1rem 0.35rem;
  font-family: inherit;
  outline: none;
}

.gpe-summary {
  margin-top: 0.75rem;
  padding: 0.75rem 1rem;
  border-radius: 0.75rem;
  background: #eef2ff;
  font-size: 0.85rem;
  color: #312e81;
}

.gpe-summary-list {
  margin: 0.5rem 0 0 1.25rem;
  padding: 0 0 0 0.25rem;
  color: #111827;
  list-style: disc;
}

.gpe-summary-list li {
  margin-bottom: 0.25rem;
  font-size: 0.82rem;
}

textarea {
  width: 100%;
  border-radius: 0.75rem;
  border: 1px solid #e2e8f0;
  padding: 0.75rem;
  font-family: inherit;
  resize: vertical;
}

.gpe-stats-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(120px, 1fr));
  gap: 0.75rem;
}

.gpe-stat {
  background: #f1f5f9;
  border-radius: 0.85rem;
  padding: 0.75rem;
  text-align: center;
  border: 1px solid transparent;
}

.gpe-stat .label {
  display: block;
  font-size: 0.7rem;
  color: #64748b;
  text-transform: uppercase;
  letter-spacing: 0.12em;
}

.gpe-stat .value {
  font-size: 1.25rem;
  font-weight: 700;
}

.gpe-stat.covered {
  background: #ecfccb;
  border-color: #a3e635;
  color: #166534;
}
.gpe-stat.covered .label,
.gpe-stat.covered .value { color: #166534; }

.gpe-stat.candidates {
  background: #dbeafe;
  border-color: #3b82f6;
  color: #1d4ed8;
}
.gpe-stat.candidates .label,
.gpe-stat.candidates .value { color: #1d4ed8; }

.gpe-stat.unknown {
  background: #fee2e2;
  border-color: #ef4444;
  color: #991b1b;
}
.gpe-stat.unknown .label,
.gpe-stat.unknown .value { color: #991b1b; }

.gpe-overlap-details {
  display: flex;
  flex-direction: column;
  gap: 0.75rem;
}

.gpe-tier-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
  gap: 1rem;
}

.gpe-tier-card {
  border: 1px solid #e5e7eb;
  border-radius: 1rem;
  padding: 1rem;
  position: relative;
  background: #fafafa;
}

.gpe-tier-card.recommended {
  border-color: #a855f7;
  box-shadow: 0 10px 30px rgba(168, 85, 247, 0.2);
}

.gpe-tier-badge {
  position: absolute;
  top: 1rem;
  right: 1rem;
  font-size: 0.65rem;
  font-weight: 700;
  color: #fff;
  background: #a855f7;
  border-radius: 999px;
  padding: 0.2rem 0.6rem;
}

.gpe-tier-title {
  font-weight: 600;
  margin-bottom: 0.5rem;
}

.gpe-tier-chips {
  display: flex;
  gap: 0.5rem;
  margin-bottom: 0.75rem;
}

.gpe-tier-chip {
  border-radius: 999px;
  font-size: 0.75rem;
  background: #fff;
  border: 1px solid #e5e7eb;
  padding: 0.15rem 0.65rem;
}

.gpe-btn-design {
  background: #111827;
  color: #fff;
  width: 100%;
  padding: 0.6rem 1rem;
}

.gpe-tools {
  display: flex;
  flex-direction: column;
  gap: 1.5rem;
}

.gpe-sidebar {
  display: flex;
  flex-direction: column;
  gap: 1.5rem;
}

@media (max-width: 1100px) {
  .gpe-layout {
    grid-template-columns: 1fr;
  }
  .gpe-hero {
    flex-direction: column;
  }
}